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28th March 2002

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Lupin introduces simplified TB treatment in India
EPP News Bureau - Bangalore

Lupin, India’s largest manufacturer of anti-TB drugs has successfully introduced AKuriT, a revolutionary simplified therapy as per WHO’s latest guidelines for treatment of tuberculosis. AkuriT, a customised therapy for patients of all weight group, is a fixed dose combination of the four essential anti-TB drugs - rifampicin, isoniazid, ethambutol and pyrazinamide (in a single tablet). India is the first Asian country where Lupin has launched AKuriT.

According to Pradeep Rane, president, Lupin Ltd, ‘‘Lupin has always been at the forefront of TB-eradication medications. TB kills more than 1000 people a day (one every minute) and the disease is spreading rampantly largely due to non-compliance to therapy. Since AKuriT is a simplified treatment, its main benefit is that it allow doctors to prescribe weight-related dosage in an ‘‘easy-to-prescribe/ easy-to-explain to patient’’ form; thereby improving chances of patient-compliance.’’

WHO in its revised guidelines has advised that the anti-TB drugs available in a fixed dose combination (FDC) can improve compliance to therapy. Further, if the patient has to be cured of TB, he has to take correct and total dosage of anti-TB medications. Formulated in keeping with WHO guidelines, AKuriT enables doctors to accurately prescribe dosage, related to the patient’s body weight. This ensures that lower weight patients are free from side effects due to higher dosing and higher weight patients do not get sub-optimal treatment. Adult weight bands identified are: Lower weight (30 to 37 kg), average weight (38 to 54 kg), higher weight (55 to 70 kg) and heavy weight (71 kg and above). Doctors can also prescribe AKuriT Kid formulations for children and younger patients.

The AKuriT range has the essential anti-TB drugs in the following combinations: AKuriT 4 - Rifampicin, Ethambutol, Isoniazid, Pyrazinamide AKuriT 3 - Rifampicin, Ethambutol, Isoniazid, AKuriT Z - Rifampicin, Isoniazid, Pyrazinamide AKuriT - Rifampicin, Isoniazid AKuriT Z Kid - Rifampicin, Isoniazid, Pyrazinamide AKuriT Kid - Rifampicin, Isoniazid AKuriT is a prescription drug, which was launched in October last year.

Leading chest physicians across India have reported superior compliance rates in treatment of TB patients with AKuriT. .

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